Ole Gunnar Solskjaer’s side go into the match in third place in the Premier League and know a win is crucial if they are to stretch their lead over West Ham in fifth.
United are looking to complete their first league double over West Ham since 2013-14, when they were managed by current West Ham boss David Moyes. The Hammers are winless in their last 12 league games at Old Trafford.
In terms of team news, Marcus Rashford is back in the United line-up after missing the draw with Milan in midweek due to an ankle problem, while Dean Henderson starts for the fourth game in succession.
United XI: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, McTominay, Fred, Greenwood, Fernandes, James, Rashford.
Subs: Grant, Bishop, Bailly, Telles, Matic, Williams, Tuanzebe, Shoretire, Amad.