Federico Bernardeschi is expected to start as a left-back for Juventus, with Dejan Kulusevski, Federico Chiesa, Alvaro Morata and Cristiano Ronaldo against Benevento.
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The Bianconeri released their squad list for the game and are without suspended Juan Cuadrado, plus injured Aaron Ramsey, Alex Sandro, Merih Demiral and Paulo Dybala.
That means Bernardeschi is the favourite to play at left-back, a role he has taken on occasionally in an emergency situation with some success.
Much as Cuadrado was an attacking right-winger and became a right-back under Maurizio Sarri, Andrea Pirlo is eager to do the same with Bernardeschi.
Giorgio Chiellini is more likely to play than Leonardo Bonucci as part of a natural squad rotation to avoid fatigue.
As always with Pirlo, Juve start in a 4-4-2 and then mutate into a 3-5-2 when going on the attack, with Chiesa and Kulusevski encouraged to bomb forward.
Arthur is expected to start in midfield with Adrien Rabiot, while Morata partners Cristiano Ronaldo.
Benevento make the trip with a reduced squad, as Kamil Glik and Pasquale Schiattarella are suspended.
Iago Falque, Gaetano Letizia and Fabio Depaoli are all on the treatment table for several weeks too.
The decisions Pippo Inzaghi has to make are between Gianluca Caprari and January signing Adolfo Gaich upfront, Andres Tello or Daam Foulon on the left wing, and Artur Ionita preferred to Bryan Dabo in midfield.
Juventus (4-4-2): Buffon; Danilo, De Ligt, Chiellini, Bernardeschi; Kulusevski, Arthur, Rabiot, Chiesa; Morata, Ronaldo
Benevento (3-5-2): Montipò; Tuia, Caldirola, Barba; Tello, Hetemaj, Viola, Ionita, Improta; Lapadula, Caprari